abstract：:Ten Egyptian women who were using the injectable contraceptive norethisterone oenanthate (NET-OEN) for at least 6 months were monitored weekly for a period of 12 weeks by measuring 3 pituitary hormones (FSH, LH and prolactin) and 2 ovarian hormones (oestradiol 17-B and progesterone). It was concluded that NET-OEN is a...

journal_title：Contraception

authors： Saleh FM,Sallam HN,Abdel-Rahman H,Souka AR,El-Sahwi SY,Toppozada HK

更新日期：1983-07-01 00:00:00

abstract：:Intramuscular injection of 200 mg norethisterone enanthate (NET-EN) was given to five women on the day of first trimester abortion. The injection was repeated twice at eight-week intervals, and thereafter at twelve-week intervals for one year. Plasma samples were collected for FSH, LH/hCG, estradiol, progesterone and ...

journal_title：Contraception

authors： Lähteenmäki P,Toivonen J,Lähteenmäki PL

更新日期：1983-06-01 00:00:00

abstract：:The effects of phenytoin treatment on plasma concentrations of norethisterone (NET) was studied in 7 healthy female rhesus monkeys. Before phenytoin treatment was started each monkey received an oral dose of 0.5 mg NET and 2 weeks later the same dose was given intravenously. On both occasions, plasma concentrations of...

journal_title：Contraception

authors： Barkfeldt JO,Odlind V,Victor A

更新日期：1983-04-01 00:00:00

abstract：:The object of this study was to investigate the effects of combined oral contraceptives on pituitary-ovarian function during the menstrual cycle of lactating women whose prolactin levels were usually elevated. Five of six lactating women studied were considered to have the normal menstrual cycle which was comparable t...

journal_title：Contraception

authors： Ryu K,Yu HK,Kwak HM,Hong SS

更新日期：1983-03-01 00:00:00

abstract：:Kauradienoic acid was obtained from the hexanic extract of M. tomentosa (Cerv) leaves by chromatographic separation. This substance influenced the in vitro contractility of the rat, dog and guinea pig uterine strips. It also induced strong contractions of the guinea pig uterus in vivo when administered intravenously, ...

journal_title：Contraception

authors： Lozoya X,Enríquez RG,Bejar E,Estrada AV,Girón H,Ponce-Monter H,Gallegos AJ

更新日期：1983-03-01 00:00:00

abstract：:A polymeric controlled release vaginal delivery system was developed for 15(S)15-methyl PGF2 alpha methyl ester. This delivery system is a reservoir-type device consisting of laminated membranes that are mounted on an inert holder. The delivery systems were designed to have in vitro steady-state release rates of 50 or...

journal_title：Contraception

authors： Bygdeman M,Christenssen N,Gréen K,Vesterqvist O,Roseman TJ,Tuttle ME,Spilman CH

更新日期：1983-02-01 00:00:00

abstract：:Seventy women with prolactinomas, age 19-38 years, were studied in order to evaluate a possible relationship between the use of steroidal oral contraceptives (o.c.) and the development of prolactin-producing adenomas. Sixty-seven patients were admitted for investigation because of menstrual bleeding disturbances and t...

journal_title：Contraception

authors： Hulting AL,Werner S,Hagenfeldt K

更新日期：1983-01-01 00:00:00

abstract：:An estimate of the menstrual blood loss (MBL) in 29 women using the Cu-7 and in 33 women using the ML-250 IUDs was carried out. None of the women who took part in the study used hormonal contraceptives or IUDs for six months previous to the study. Before the insertion of the IUD, the MBL of each woman was measured for...

journal_title：Contraception

authors： Pedrón N,Gallegos AJ,Lozano M,Aznar R

更新日期：1982-11-01 00:00:00

abstract：:The possibility of permanent sterility following use of modern contraceptive agents is a concept which causes great concern amongst members of the lay public. However, a thorough review of the literature gives a great deal of reassurance on this topic. The combined oral contraceptive pill causes slight delay, and the ...

journal_title：Contraception

authors： Fraser IS,Weisberg E

更新日期：1982-10-01 00:00:00

abstract：:The leucocytes adhering to intrauterine devices (IUDs) were predominantly mononuclear phagocytic cells (MPCs) and granulocytes. These cells released elastase and a plasminogen activator in the culture medium. The plasminogen activator was found to be immunologically identical to tissue activator, and the release patte...

journal_title：Contraception

authors： Casslén B,Ohlsson K,Lindholm K,Astedt B

更新日期：1982-08-01 00:00:00

abstract：:A multicentre randomized clinical trial of the TCu220C, Lippes Loop D and Copper 7 was undertaken in nine WHO Collaborating centres for Clinical Research in Human Reproduction. A total of 984, 992 and 994 devices, respectively, were inserted between 1976 and 1978. The subjects were followed for two years. At this time...

journal_title：Contraception

authors：

更新日期：1982-07-01 00:00:00

abstract：:LHRH and three potent antagonistic analogs: z-[Gln1, des-His2,D-Pse6,des-Gly10]-LHRH ethylamide, where D-Pse = threo-D-phenylserine; z-[Gln1,des-His2,D-Phe6,des-Gly10]-LHRH ethylamide; and Boc-[Ser(Bzl)1,des-His2,D-Trp6]-LHRH; were studied for their effects on blood pressure and heart rate in chronically catheterized ...

journal_title：Contraception

authors： Smith RD,Edgren RA

更新日期：1982-04-01 00:00:00

abstract：:The clinical performance of two levonorgestrel-releasing intrauterine devices (IUDs) with different release rates was studied and compared with a copper-releasing Nova-T device in a randomized partly double-blind multiclinical trial. Special attention was given to patterns of bleeding, hormonal side-effects, blood pre...

journal_title：Contraception

authors： Nilsson CG,Luukkainen T,Diaz J,Allonen H

更新日期：1982-04-01 00:00:00

abstract：:Sulprostone was given intramuscularly in two dose schedules of 0.5 mg at 4 hourly intervals for 8 doses and 1.0 mg at 8-hour intervals for 4 doses to 56 women in the 12th-20th week of gestation coming for termination of pregnancy. Forty-nine of them aborted within the 30-hour observation period, giving a success rate ...

journal_title：Contraception

authors： Ranjan V,Hingorani V,Kinra G,Agarwal N,Pande Y

更新日期：1982-02-01 00:00:00

abstract：:Phospholipases A2 and C (93 and 500 mU) were administered to uterine horns of Long-Evans adult rats during the first five days of pregnancy. As control material, saline (0.15 M) was administered to contralateral uterine horns. The animals were sacrificed on the ninth day of pregnancy, the uterine horns were removed an...

journal_title：Contraception

authors： Vilar-Rojas C,Ruiz de Chávez I,González-Angulo A,Hicks JJ

更新日期：1982-01-01 00:00:00

abstract：:The potent luteinizing hormone-releasing hormone (LRH) agonist D-Ser(TBU)6-EA10-LRH was administered in a daily subcutaneous dose of 5 or 25 microgram for 1, 3 or 5 consecutive days to twelve regularly menstruating women in the early follicular phase of the menstrual cycle in an attempt to disturb follicular maturatio...

journal_title：Contraception

authors： Skarin G,Nillius SJ,Wide L

更新日期：1982-01-01 00:00:00

abstract：:The influence of copper ions on myometrial activity was tested in nonpregnant rabbits in vitro and in vivo, and nonpregnant women in vivo. In an organ bath, CuCl2 in concentrations of 3 micro M and higher caused a dose-dependent increase in the contractile activity of isolated rabbit myometrium. In rabbits in vivo, in...

journal_title：Contraception

authors： Laundański T,Kobylec E,Akerlund M

更新日期：1981-08-01 00:00:00

abstract：:Pituitary and ovarian function was evaluated in women receiving 3 combined oral contraceptive preparations. Basal levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) and gonadotropic responses to gonadotropic releasing hormone (GnRH) were studied in 36 healthy, regularly ovulating women in the ea...

journal_title：Contraception

authors： Cohen BL,Katz M

更新日期：1981-08-01 00:00:00

abstract：:Twenty normotensive and ten hypertensive black women taking oral contraceptive (OC) were studied. Age, body weight, family medical history of hypertension, length of OC use, and type of OC were comparable. At midcycle approximately 10-12 hours following OC intake, blood was drawn and the plasma was used to determine e...

journal_title：Contraception

authors： Kaul L,Curry CL,Ahluwalia BS

更新日期：1981-06-01 00:00:00

abstract：:Information relating to the effect of steroids on the metabolism and motility of human spermatozoa is limited despite the increasing interest in the use of these hormones for the purpose of contraception. In the present study it was shown that progesterone, testosterone, and 11-beta-OH-progesterone significantly inhib...

journal_title：Contraception

authors： Trifunac NP,Bernstein GS

更新日期：1981-05-01 00:00:00

abstract：:Data from published studies of the quantity of medroxyprogesterone acetate and/or its metabolites in the milk of lactating women receiving Depo-Provera for contraception is extrapolated into the amount of drug ingested daily by a theoretically average infant. Comparisons are made with the results of similar studies in...

journal_title：Contraception

authors： Schwallie PC

更新日期：1981-04-01 00:00:00

abstract：:A study has been made of the serum 25-hydroxycholecalciferol (25-HCC) levels in six groups of women. Significant differences were found between the one pregnant group and the two reference groups as well as between the one pregnant group and two of the three groups using oral contraceptives. No significant differences...

journal_title：Contraception

authors： Schreurs WH,van Rijn HJ,van den Berg H

更新日期：1981-04-01 00:00:00

abstract：:Levels of immunoreactive follitropin (FSH), lutropin (LH), estradiol, progesterone, 17-hydroxyprogesterone and 20 alpha-dihydroprogesterone were analyzed in peripheral plasma samples collected daily from 21 normally menstruating women during a pretreatment (control) cycle and during months 2 and 6 of administration of...

journal_title：Contraception

authors： Landgren BM,Lager S,Diczfalusy E

更新日期：1981-03-01 00:00:00

abstract：:Norethisterone oenanthate (NET OEN) was extensively hydrolysed in rabbit, rat and guinea pig plasma (99.9%, 76.1% and 46.0% hydrolysed in 90 min, respectively). In contrast, there was negligible hydrolysis (less than 2.5%) in dog, goat and human plasma. Rabbit liver, kidney, gut wall, stomach, heart and muscle showed ...

journal_title：Contraception

authors： Back DJ,Breckenridge AM,Chapman CR,Crawford FE,Olsen KA,Orme ML,Rowe PH

更新日期：1981-02-01 00:00:00

abstract：:Eight investigators, using a common protocol, studied the use of intramuscular (15S)-15-methyl prostaglandin F2 alpha to abort midtrimester pregnancies which had failed treatment by other methods in 398 cases. Results of treatment of 3 subgroups, defined by reason for primary treatment failure, are presented. The comb...

journal_title：Contraception

authors： Schwallie PC,Huang DC,Turner LF

更新日期：1980-12-01 00:00:00

abstract：:Cyproterone acetate (CPA) was administered in a dose of 50 mg to 6 lactating women delivered by caesarean section. All women had to discontinue breast feeding the day before treatment. Prior to, and 3 and 9 hours after ingestion of the drug, plasma and milk specimens were taken. Total daily milk volume was recorded. C...

journal_title：Contraception

authors： Stoppelli I,Rainer E,Hümpel M

更新日期：1980-11-01 00:00:00

abstract：:The effect of alpha-chlorohydrin (3-chloropropan-1,2-diol) on the metabolism of D-[U-14C]-fructose and L-[U-14C]-lactate by washed boar sperm has been investigated. Whereas alpha-chlorohydrin at concentrations as low as 0.1 mM inhibited the metabolism of fructose and led to an increase in the utilization of endogenous...

journal_title：Contraception

authors： Hutton P,Dawson AG,Jones AR

更新日期：1980-11-01 00:00:00

abstract：:The incidence of gonorrhea was investigated in an abortion population. A total of 1021 women participated in this study. Three asymptomatic cases of gonorrhea were detected. None of these women had had gonorrhea before or had a previous abortion. No relation was found between the incidence of gonorrhea and age. The ab...

journal_title：Contraception

authors： Querido L,Haspels AA

更新日期：1980-10-01 00:00:00

abstract：:In a study of 1074 women, 696 and 338 subjects would not seriously consider permanent and hypothetically reversible sterilization, respectively; they were asked to explain their feelings. The reason accounting for most objections to permanent sterilization (65%) was irreversibility and of the subjects who would not co...

journal_title：Contraception

authors： Shain RN

更新日期：1980-09-01 00:00:00

abstract：:9-Deoxo-16, 16-dimethyl-9-methylene-PGE2 is a new prostaglandin analogue which is stable in suppository form. Estimates of potential for gastrointestinal side effects in monkey in vivo indicated that the frequency of diarrhea was low with retention of uterine stimulating potency. In the present study the effect of the...

journal_title：Contraception

authors： Bygdeman M,Christensen N,Gréen K,Lundström V

更新日期：1980-08-01 00:00:00

abstract：:A single intratesticular injection of TEPA or Thio-TEPA induced a period of infertility lasting 1-2 months. Restoration of fertility was characterized by a reduction of the litter size resulting from the first inpregnation post-treatment. There was no evidence of tissue pathogenesis 6-12 months after treatment. ...

journal_title：Contraception

authors： Howe GR,Steward R

更新日期：1980-08-01 00:00:00

abstract：:A multinational comparative trial of three IUDs (Copper 7, Lippes loop size D and the Postpartum T) randomly inserted immediately following delivery of the placenta was conducted in six centres. A total of 841 women entered the study. As the predetermined termination indices for expulsions were exceeded at six months ...

journal_title：Contraception

authors：

更新日期：1980-07-01 00:00:00

abstract：:A chemically deglycosylated derivative of ovine luteinizing hormone (LH) exhibited appreciable binding to the receptor but had minimal steroidogenic activity. In immature female rats primed with pregnant mare serum gonadotropin, the deglycosylated LH showed low ovulation-inducing activity. Ovulation induced by ovine L...

journal_title：Contraception

authors： Sairam MR

更新日期：1980-06-01 00:00:00

abstract：:In one of the first longitudinal studies of 163 non-Caucasian women, comprehensive coagulation, fibrinolysis and platelet function tests were performed before and during 24 months of oral contraceptive pill usage containing 50 microgram estrogen. Results of this ongoing study indicate a state of abnormal coagulability...

journal_title：Contraception

authors： Tsakok FH,Koh S,Ratnam SS

更新日期：1980-05-01 00:00:00

abstract：:Plasma concentrations of levonorgestrel, progesterone, estradiol, FSH and LH were measured in seven volunteers who had a levonorgestrel-releasing IUD inserted postmenstrually. Blood samples were collected twice weekly during a mean of 93 days immediately postmenstrually and during a mean of 41 days over the twelfth to...

journal_title：Contraception

authors： Nilsson CG,Lähteenmäki P,Luukkainen T

更新日期：1980-03-01 00:00:00

abstract：:The release of contraceptive steroids through different drug delivery systems into serum and breast milk was investigated in a group of lactating women. Four women in each group were taking either a low dosage progestogen compound like norethisterone (NET) 350 micrograms or d-norgestrel (d-Ng) 50 micrograms alone or l...

journal_title：Contraception

authors： Toddywalla VS,Mehta S,Virkar KD,Saxena BN

更新日期：1980-03-01 00:00:00

abstract：:The effect of continuous release of microquantities of cyproterone acetate from subcutaneously implanted silastic capsules on the fertility of surgically manipulated seminal vesicles of rat has been studied. The experimental animals showed infertility for 3 weeks, as a consequence of removal of seminal plasma, followi...

journal_title：Contraception

authors： Nayyar SK,Ghosh T

更新日期：1980-02-01 00:00:00

abstract：:Patterns of bleeding and plasma concentrations of levonorgestrel, progesterone, estradiol, LH and FSH were studied in ten volunteers who had a levonorgestrel-releasing IUD inserted postmenstrually. The IUD was designed to release 12 microgram/day. All but two of the volunteers ovulated during treatment. The ovulatory ...

journal_title：Contraception

authors： Nilsson CG,Lähteenmäki P,Luukkainen T

更新日期：1980-02-01 00:00:00

abstract：:STS 557 (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4.9(10)-diene-3-one) is a potent progestin. This compound was 10 times as potent as the standard levonorgestrel as judged by the classic Clauberg-McPhail Assay. The antiprogestational response is significant when STS 557 treatment starts 2 days before progesterone ad...

journal_title：Contraception

authors： Oettel M,Kurischko A

更新日期：1980-01-01 00:00:00

abstract：:A report that serum prolactin concentrations were almost doubled by the use of copper IUDs led us to study the effect of both copper and inert IUDs. We studied 105 normal women in whom all other prolactinergic factors had been excluded; 25 of them were using copper IUDs, 25 were using inert IUDs and there were 55 cont...

journal_title：Contraception

authors： Ransom WT,Chapman RS,Hull MG

更新日期：1979-11-01 00:00:00